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By cells isolated from your synovial membrane. J Autoimmun 1989, 2(Suppl):177-186. 29. Uchida T, Rossignol F, Matthay MA, Mounier R, Couette S, Clottes E, Clerici C: Prolonged hypoxia differentially regulates hypoxia-inducible element (HIF)-1 and HIF-2 expression in lung epithelial cells: implication of natural antisense HIF-1. J Biol Chem 2004, 279:14871-14878. thirty. Livak KJ, Schmittgen TD: Analysis of relative gene expression data employing real-time quantitative PCR along with the 2(-C(T)) approach. Procedures 2001, twenty five:402-408. 31. Del Rey MJ, Izquierdo E, Usategui A, Gonzalo E, Blanco FJ, Acquadro F, Pablos JL: The transcriptional response of standard and rheumatoid arthritis synovial fibroblasts to hypoxia. Arthritis Rheum 2010, sixty two:3584-3594. 32. Ambrosini G, Nath AK, Sierra-Honigmann MR, Flores-Riveros J: Transcriptional activation on the human leptin gene in reaction to hypoxia. Involvement of hypoxia-inducible aspect 1. J Biol Chem 2002, 277:34601-34609. 33. Cascio S, Bartella V, Auriemma A, Johannes GJ, Russo A, Giordano A, Surmacz E: System of leptin expression in breast most cancers cells: part of hypoxia-inducible factor-1. Oncogene 2008, 27:540-547. 34. Grosfeld A, Andre J, Hauguel-De Mouzon S, Berra E, Pouyssegur J, GuerreMillo M: Hypoxia-inducible factor 1 transactivates the human leptin gene promoter. J Biol Chem 2002, 277:42953-42957. 35. Belanger AJ, Lu H, Day T, Liu LX, Vincent KA, Akita GY, Cheng SH, Gregory PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26278330 RJ, Jiang C: Hypoxia up-regulates expression of peroxisome proliferator-activated receptor gamma angiopoietin-related gene (PGAR) in cardiomyocytes: role of hypoxia inducible element 1. J Mol Mobile Cardiol 2002, 34:765-774. 36. Fasanaro P, D'Alessandra Y, Di Stefano V, Melchionna R, Romani S, Pompilio G, Capogrossi MC, Martelli F: MicroRNA-210 modulates endothelial cell reaction to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. J Biol Chem 2008, 283:15878-15883. 37. Merlos-Suarez A, Desidustat Batlle E: Eph-ephrin signalling in grownup tissues and cancer. Curr Opin Mobile Biol 2008, twenty:194-200. 38. Brantley DM, Cheng N, Thompson EJ, Lin Q, Brekken RA, Thorpe PE, Muraoka RS, Cerretti DP, Pozzi A, Jackson D: Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene 2002, 21:7011-7026. 39. Bouloumie A, Drexler HC, Lafontan M, Busse R: Leptin, the item of Ob gene, encourages angiogenesis. Circ Res 1998, 83:1059-1066. forty. Lago F, Dieguez C, Gomez-Reino J, Gualillo O: Adipokines as emerging mediators of immune response and irritation. Nat Clin Pract Rheumatol 2007, three:716-724. forty one. Gabriel SE, Michaud K: Epidemiological reports in incidence, prevalence, mortality, and comorbidity of your rheumatic illnesses. Arthritis Res Ther 2009, eleven:229. 42. Van Doornum S, Manufacturer C, King B, Sundararajan V: Improved situation fatality fees following a primary acute cardiovascular party in clients with rheumatoid arthritis. Arthritis Rheum 2006, 54:2061-2068. 43. Hermann LM, Pinkerton M, Jennings K, Yang L, Grom A, Sowders D, Kersten S, Witte DP, Hirsch R, Thornton S: Angiopoietin-like-4 is a potential angiogenic mediator in arthritis. Clin Immunol 2005, one hundred fifteen:93-101. 44. Muz B, Larsen H, Madden L, Kiriakidis S, Paleolog EM: Prolyl hydroxylase area enzyme-2 will be the important participant in regulating hypoxic responses in rheumatoid arthritis. Arthritis Rheum 2012, PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28570735 64:2856-2867. 45. Thrash-Bingham CA, Tartof KD: aHIF: a all-natural antisense transcript overexpressed in human renal cancer and through hypoxia. J Natl Cancer Inst 1999, ninety one:143-151. 46.
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